Lifestyle alterations for peripheral arterial disease

The Grenon lab conducts basic science investigations and clinical studies on the effect of lifestyle changes and physical inactivity in patients with cardiovascular diseases and peripheral arterial disease (PAD). For example, the lab investigates the effects of omega-3 fatty acids on inflammation and endothelial function in patients with PAD. We also examine parallels between the physical deconditioning in astronauts during spaceflight with those average people who do not exercise. We are interested in determining how factors in everyday life can impact the development of lower atherosclerotic disease and cardiovascular diseases, and we hope to target specific therapies or programs to help with these diseases.

Recent Publications

Grenon SM, Chong K, Alley H, Nosova E, Gasper W, Hiramoto J, Boscardin WJ, Owens CD
Walking disability in patients with peripheral artery disease is associated with arterial endothelial function.
Journal of vascular surgery, Apr-01-2014; 594: 1025-34.  Epub 2014 Jan 11.
Owens CD, Gasper WJ, Walker JP, Alley HF, Conte MS, Grenon SM
Safety and feasibility of adjunctive dexamethasone infusion into the adventitia of the femoropopliteal artery following endovascular revascularization.
Journal of vascular surgery, Apr-01-2014; 594: 1016-24.  Epub 2014 Jan 11.
Grenon SM, Cohen BE, Smolderen K, Vittinghoff E, Whooley MA, Hiramoto J
Peripheral arterial disease, gender, and depression in the Heart and Soul Study.
Journal of vascular surgery, Mar-22-2014; [Epub ahead of print].
Nosova EV, Yen P, Chong KC, Alley HF, Stock EO, Quinn A, Hellmann J, Conte MS, Owens CD, Spite M, Grenon SM
Short-term physical inactivity impairs vascular function.
The Journal of surgical research, Feb-12-2014; [Epub ahead of print].
Grenon SM, Conte MS, Nosova E, Alley H, Chong K, Harris WS, Vittinghoff E, Owens CD
Association between n-3 polyunsaturated fatty acid content of red blood cells and inflammatory biomarkers in patients with peripheral artery disease.
Journal of vascular surgery, Nov-01-2013; 585: 1283-90.  Epub 2013 Jul 2.
Grenon SM, Owens CD, Alley H, Chong K, Yen PK, Harris W, Hughes-Fulford M, Conte MS
n-3 Polyunsaturated fatty acids supplementation in peripheral artery disease: the OMEGA-PAD trial.
Vascular medicine (London, England), Oct-01-2013; 185: 263-74.  Epub 2013 Sep 19.
Grenon SM, Vittinghoff E, Owens CD, Conte MS, Whooley M, Cohen BE
Peripheral artery disease and risk of cardiovascular events in patients with coronary artery disease: insights from the Heart and Soul Study.
Vascular medicine (London, England), Aug-01-2013; 184: 176-84.  Epub 2013 Jul 8.
Gasper WJ, Reilly LM, Rapp JH, Grenon SM, Hiramoto JS, Sobel JD, Chuter TA
Assessing the anatomic applicability of the multibranched endovascular repair of thoracoabdominal aortic aneurysm technique.
Journal of vascular surgery, Jun-01-2013; 576: 1553-8; discussion 1558.  Epub 2013 Feb 6.
Grenon SM, Jeanne M, Aguado-Zuniga J, Conte MS, Hughes-Fulford M
Effects of gravitational mechanical unloading in endothelial cells: association between caveolins, inflammation and adhesion molecules.
Scientific reports, 3: 1494.
Grenon SM, Aguado-Zuniga J, Hatton JP, Owens CD, Conte MS, Hughes-Fulford M
Effects of fatty acids on endothelial cells: inflammation and monocyte adhesion.
The Journal of surgical research, Sep-01-2012; 1771: e35-43.  Epub 2012 Apr 27.
Grenon SM, Hiramoto J, Smolderen KG, Vittinghoff E, Whooley MA, Cohen BE
Association between depression and peripheral artery disease: insights from the heart and soul study.
Journal of the American Heart Association, Aug-01-2012; 14: e002667.
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