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Principal Investigator

Marlene Grenon, M.D., C. M.

Assistant Professor
Division of Vascular and Endovascular Surgery

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Lifestyle alterations for peripheral arterial disease

The Grenon lab conducts basic science investigations and clinical studies on the effect of lifestyle changes and physical inactivity in patients with cardiovascular diseases and peripheral arterial disease (PAD). For example, the lab investigates the effects of omega-3 fatty acids on inflammation and endothelial function in patients with PAD. We also examine parallels between the physical deconditioning in astronauts during spaceflight with those average people who do not exercise. We are interested in determining how factors in everyday life can impact the development of lower atherosclerotic disease and cardiovascular diseases, and we hope to target specific therapies or programs to help with these diseases.

Recent Publications

Grenon SM, Aguado-Zuniga J, Hatton JP, Owens CD, Conte MS, Hughes-Fulford M

Effects of fatty acids on endothelial cells: inflammation and monocyte adhesion.

The Journal of surgical research, Sep-01-2012; 1771: e35-43. Epub 2012 Apr 27.

PubMed Abstract

Grenon SM, Hiramoto J, Smolderen KG, Vittinghoff E, Whooley MA, Cohen BE

Association between depression and peripheral artery disease: insights from the heart and soul study.

Journal of the American Heart Association, Aug-01-2012; 14: e002667.

PubMed Abstract

Reilly LM, Rapp JH, Grenon SM, Hiramoto JS, Sobel J, Chuter TA

Efficacy and durability of endovascular thoracoabdominal aortic aneurysm repair using the caudally directed cuff technique.

Journal of vascular surgery, Jul-01-2012; 561: 53-63; discussion 63-4. Epub 2012 May 3.

PubMed Abstract

Grenon SM, Hughes-Fulford M, Rapp J, Conte MS

Polyunsaturated fatty acids and peripheral artery disease.

Vascular medicine (London, England), Feb-01-2012; 171: 51-63.

PubMed Abstract

Grenon SM, Saary J, Gray G, Vanderploeg JM, Hughes-Fulford M

Can I take a space flight? Considerations for doctors.

BMJ (Clinical research ed.), [epublish] 345: e8124.

PubMed Abstract

Grenon SM, Saary J

Challenges in aerospace medicine education.

Aviation, space, and environmental medicine, Nov-01-2011; 8211: 1071-2.

PubMed Abstract

Grenon SM, Reilly LM, Ramaiah VG

Technical endovascular highlights for crossing the difficult aortic bifurcation.

Journal of vascular surgery, Sep-01-2011; 543: 893-6. Epub 2011 Jun 12.

PubMed Abstract

Grenon SM, Reid JD, Clement J

A late complication of migration after aortic endografting: injury to the superior mesenteric artery.

Journal of vascular and interventional radiology : JVIR, Jul-01-2011; 227: 1055-7.

PubMed Abstract

Grenon SM, Conte MS

Aspirin prophylaxis (100 mg daily) does not improve cardiovascular outcomes compared to placebo in asymptomatic individuals with incidental low-ankle brachial index.

Evidence-based medicine, Aug-01-2010; 154: 106-8. Epub 2010 Jun 8.

PubMed Abstract

Grenon SM, Gagnon J, Hsiang Y, Sidhu R, Taylor D, Clement J, Chen J

Occlusion of the common and internal iliac arteries for aortoiliac aneurysm repair: experience with the Amplatzer vascular plug.

Canadian journal of surgery. Journal canadien de chirurgie, Dec-01-2009; 526: E276-80.

PubMed Abstract

Grenon SM, Gagnon J, Hsiang Y

Video in clinical medicine. Ankle-brachial index for assessment of peripheral arterial disease.

The New England journal of medicine, Nov-05-2009; 36119: e40.

PubMed Abstract

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